Editing of the TRIM5 Gene Decreases the Permissiveness of Human T Lymphocytic Cells to HIV-1

Tripartite-motif-containing protein 5 isoform α (TRIM5α) is a cytoplasmic antiretroviral effector upregulated by type I interferons (IFN-I). We previously showed that two points mutations, R332G/R335G, in the retroviral capsid-binding region confer human TRIM5α the capacity to target and strongly re...

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Detalhes bibliográficos
Publicado no:Viruses
Main Authors: Désaulniers, Kevin, Ortiz, Levine, Dufour, Caroline, Claudel, Alix, Plourde, Mélodie B., Merindol, Natacha, Berthoux, Lionel
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7824555/
https://ncbi.nlm.nih.gov/pubmed/33375604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v13010024
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