HIV-1 capsids from B27/B57(+) elite controllers escape Mx2 but are targeted by TRIM5α, leading to the induction of an antiviral state

Elite controllers (ECs) are a rare subset of HIV-1 slow progressors characterized by prolonged viremia suppression. HLA alleles B27 and B57 promote the cytotoxic T lymphocyte (CTL)-mediated depletion of infected cells in ECs, leading to the emergence of escape mutations in the viral capsid (CA). Whe...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Merindol, Natacha, El-Far, Mohamed, Sylla, Mohamed, Masroori, Nasser, Dufour, Caroline, Li, Jia-xin, Cherry, Pearl, Plourde, Mélodie B., Tremblay, Cécile, Berthoux, Lionel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258467/
https://ncbi.nlm.nih.gov/pubmed/30419009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007398
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