Editing of the human TRIM5 gene to introduce mutations with the potential to inhibit HIV-1

The type I interferon (IFN-I)-inducible human restriction factor TRIM5α inhibits the infection of human cells by specific nonhuman retroviruses, such as N-MLV and EIAV, but does not generally target HIV-1. However, the introduction of two aminoacid substitutions, R332G and R355G, in the human TRIM5α...

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Detalhes bibliográficos
Publicado no:PLoS One
Principais autores: Dufour, Caroline, Claudel, Alix, Joubarne, Nicolas, Merindol, Natacha, Maisonnet, Tara, Masroori, Nasser, Plourde, Mélodie B., Berthoux, Lionel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786314/
https://ncbi.nlm.nih.gov/pubmed/29373607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191709
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