The V86M mutation in HIV-1 capsid confers resistance to TRIM5α by abrogation of cyclophilin A-dependent restriction and enhancement of viral nuclear import

BACKGROUND: HIV-1 is inhibited early after entry into cells expressing some simian orthologues of the tripartite motif protein family member TRIM5α. Mutants of the human orthologue (TRIM5α(hu)) can also provide protection against HIV-1. The host protein cyclophilin A (CypA) binds incoming HIV-1 caps...

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Bibliographic Details
Main Authors: Veillette, Maxime, Bichel, Katsiaryna, Pawlica, Paulina, Freund, Stefan M V, Plourde, Mélodie B, Pham, Quang Toan, Reyes-Moreno, Carlos, James, Leo C, Berthoux, Lionel
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598646/
https://ncbi.nlm.nih.gov/pubmed/23448277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-25
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