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In situ kinetic measurements of α-synuclein aggregation reveal large population of short-lived oligomers

Knowledge of the mechanisms of assembly of amyloid proteins into aggregates is of central importance in building an understanding of neurodegenerative disease. Given that oligomeric intermediates formed during the aggregation reaction are believed to be the major toxic species, methods to track such...

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Publicado en:PLoS One
Autores principales: Zurlo, Enrico, Kumar, Pravin, Meisl, Georg, Dear, Alexander J., Mondal, Dipro, Claessens, Mireille M. A. E., Knowles, Tuomas P. J., Huber, Martina
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7822277/
https://ncbi.nlm.nih.gov/pubmed/33481908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0245548
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