DNA-thioguanine nucleotide as a treatment marker in acute lymphoblastic leukemia patients with NUDT15 variant genotypes

BACKGROUND: Large inter-individual variations in drug metabolism pose a challenge in determining 6-mercaptopurine (6MP) doses. As the last product of 6MP metabolism, DNA-thioguanine nucleotide (DNA-TGN) could reflect the efficacy of 6MP, especially in patients harboring variants in the 6MP metabolis...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Ju, Hee Young, Lee, Ji Won, Cho, Hee Won, Hyun, Ju Kyung, Ma, Youngeun, Yi, Eun Sang, Yoo, Keon Hee, Sung, Ki Woong, Choi, Rihwa, Koo, Hong Hoe, Lee, Soo-Youn
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7822258/
https://ncbi.nlm.nih.gov/pubmed/33481917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0245667
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