NUDT15 Variants Cause Hematopoietic Toxicity with Low 6-TGN Levels in Children with Acute Lymphoblastic Leukemia

PURPOSE: We aimed to identify the impact of NUDT15 variants on thiopurine intolerance and 6-thioguanine nucleotide (6-TGN) levels in Korean children with acute lymphoblastic leukemia (ALL). MATERIALS AND METHODS: Genotyping of NUDT15 was tested in 258 patients with ALL registered at Samsung Medical...

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Detalhes bibliográficos
Publicado no:Cancer Res Treat
Main Authors: Yi, Eun Sang, Choi, Young Bae, Choi, Rihwa, Lee, Na Hee, Lee, Ji Won, Yoo, Keon Hee, Sung, Ki Woong, Lee, Soo-Youn, Koo, Hong Hoe
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Cancer Association 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056957/
https://ncbi.nlm.nih.gov/pubmed/28903549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4143/crt.2017.283
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