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NUDT15 Polymorphisms Alter Thiopurine Metabolism and Hematopoietic Toxicity
Widely used as anti-cancer and immunosuppressive agents, thiopurines have narrow therapeutic indices due to frequent toxicities, partly explained by TPMT genetic polymorphisms. Recent studies identified germline NUDT15 variation as another critical determinant of thiopurine intolerance, but the unde...
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| Published in: | Nat Genet |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5029084/ https://ncbi.nlm.nih.gov/pubmed/26878724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3508 |
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