NUDT15 Polymorphisms Alter Thiopurine Metabolism and Hematopoietic Toxicity

Widely used as anti-cancer and immunosuppressive agents, thiopurines have narrow therapeutic indices due to frequent toxicities, partly explained by TPMT genetic polymorphisms. Recent studies identified germline NUDT15 variation as another critical determinant of thiopurine intolerance, but the unde...

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Gepubliceerd in:Nat Genet
Hoofdauteurs: Moriyama, Takaya, Nishii, Rina, Perez-Andreu, Virginia, Yang, Wenjian, Klussmann, Federico Antillon, Zhao, Xujie, Lin, Ting-Nien, Hoshitsuki, Keito, Nersting, Jacob, Kihira, Kentaro, Hofmann, Ute, Komada, Yoshihiro, Kato, Motohiro, McCorkle, Robert, Li, Lie, Koh, Katsuyoshi, Najera, Cesar Rolando, Kham, Shirley Kow-Yin, Isobe, Tomoya, Chen, Zhiwei, Chiew, Edwynn Kean-Hui, Bhojwani, Deepa, Jeffries, Cynthia, Lu, Yan, Schwab, Matthias, Inaba, Hiroto, Pui, Ching-Hon, Relling, Mary V., Manabe, Atsushi, Hori, Hiroki, Schmiegelow, Kjeld, Yeoh, Allen E. J., Evans, William E., Yang, Jun J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029084/
https://ncbi.nlm.nih.gov/pubmed/26878724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3508
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