NUDT15 Polymorphisms Alter Thiopurine Metabolism and Hematopoietic Toxicity

Widely used as anti-cancer and immunosuppressive agents, thiopurines have narrow therapeutic indices due to frequent toxicities, partly explained by TPMT genetic polymorphisms. Recent studies identified germline NUDT15 variation as another critical determinant of thiopurine intolerance, but the unde...

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Foilsithe in:Nat Genet
Main Authors: Moriyama, Takaya, Nishii, Rina, Perez-Andreu, Virginia, Yang, Wenjian, Klussmann, Federico Antillon, Zhao, Xujie, Lin, Ting-Nien, Hoshitsuki, Keito, Nersting, Jacob, Kihira, Kentaro, Hofmann, Ute, Komada, Yoshihiro, Kato, Motohiro, McCorkle, Robert, Li, Lie, Koh, Katsuyoshi, Najera, Cesar Rolando, Kham, Shirley Kow-Yin, Isobe, Tomoya, Chen, Zhiwei, Chiew, Edwynn Kean-Hui, Bhojwani, Deepa, Jeffries, Cynthia, Lu, Yan, Schwab, Matthias, Inaba, Hiroto, Pui, Ching-Hon, Relling, Mary V., Manabe, Atsushi, Hori, Hiroki, Schmiegelow, Kjeld, Yeoh, Allen E. J., Evans, William E., Yang, Jun J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029084/
https://ncbi.nlm.nih.gov/pubmed/26878724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3508
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