NUDT15 Polymorphisms Alter Thiopurine Metabolism and Hematopoietic Toxicity

Widely used as anti-cancer and immunosuppressive agents, thiopurines have narrow therapeutic indices due to frequent toxicities, partly explained by TPMT genetic polymorphisms. Recent studies identified germline NUDT15 variation as another critical determinant of thiopurine intolerance, but the unde...

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Published in:Nat Genet
Main Authors: Moriyama, Takaya, Nishii, Rina, Perez-Andreu, Virginia, Yang, Wenjian, Klussmann, Federico Antillon, Zhao, Xujie, Lin, Ting-Nien, Hoshitsuki, Keito, Nersting, Jacob, Kihira, Kentaro, Hofmann, Ute, Komada, Yoshihiro, Kato, Motohiro, McCorkle, Robert, Li, Lie, Koh, Katsuyoshi, Najera, Cesar Rolando, Kham, Shirley Kow-Yin, Isobe, Tomoya, Chen, Zhiwei, Chiew, Edwynn Kean-Hui, Bhojwani, Deepa, Jeffries, Cynthia, Lu, Yan, Schwab, Matthias, Inaba, Hiroto, Pui, Ching-Hon, Relling, Mary V., Manabe, Atsushi, Hori, Hiroki, Schmiegelow, Kjeld, Yeoh, Allen E. J., Evans, William E., Yang, Jun J.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029084/
https://ncbi.nlm.nih.gov/pubmed/26878724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3508
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