Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity

As a prototype of genomics-guided precision medicine, individualized thiopurine dosing based on pharmacogenetics is a highly effective way to mitigate hematopoietic toxicity of this class of drugs. Recently, NUDT15 deficiency was identified as a genetic cause of thiopurine toxicity, and NUDT15-infor...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Suiter, Chase C., Moriyama, Takaya, Matreyek, Kenneth A., Yang, Wentao, Scaletti, Emma Rose, Nishii, Rina, Yang, Wenjian, Hoshitsuki, Keito, Singh, Minu, Trehan, Amita, Parish, Chris, Smith, Colton, Li, Lie, Bhojwani, Deepa, Yuen, Liz Y. P., Li, Chi-kong, Li, Chak-ho, Yang, Yung-li, Walker, Gareth J., Goodhand, James R., Kennedy, Nicholas A., Klussmann, Federico Antillon, Bhatia, Smita, Relling, Mary V., Kato, Motohiro, Hori, Hiroki, Bhatia, Prateek, Ahmad, Tariq, Yeoh, Allen E. J., Stenmark, Pål, Fowler, Douglas M., Yang, Jun J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2020
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071893/
https://ncbi.nlm.nih.gov/pubmed/32094176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915680117
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