Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity

As a prototype of genomics-guided precision medicine, individualized thiopurine dosing based on pharmacogenetics is a highly effective way to mitigate hematopoietic toxicity of this class of drugs. Recently, NUDT15 deficiency was identified as a genetic cause of thiopurine toxicity, and NUDT15-infor...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Suiter, Chase C., Moriyama, Takaya, Matreyek, Kenneth A., Yang, Wentao, Scaletti, Emma Rose, Nishii, Rina, Yang, Wenjian, Hoshitsuki, Keito, Singh, Minu, Trehan, Amita, Parish, Chris, Smith, Colton, Li, Lie, Bhojwani, Deepa, Yuen, Liz Y. P., Li, Chi-kong, Li, Chak-ho, Yang, Yung-li, Walker, Gareth J., Goodhand, James R., Kennedy, Nicholas A., Klussmann, Federico Antillon, Bhatia, Smita, Relling, Mary V., Kato, Motohiro, Hori, Hiroki, Bhatia, Prateek, Ahmad, Tariq, Yeoh, Allen E. J., Stenmark, Pål, Fowler, Douglas M., Yang, Jun J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071893/
https://ncbi.nlm.nih.gov/pubmed/32094176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915680117
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