Quantification of Thioguanine in DNA Using Liquid Chromatography-Tandem Mass Spectrometry for Routine Thiopurine Drug Monitoring in Patients With Pediatric Acute Lymphoblastic Leukemia

BACKGROUND: We developed an assay to measure DNA-incorporated 6-thioguanine (DNA-TG) and validated its clinical applicability in Korean pediatric patients with acute lymphoblastic leukemia (ALL) in order to improve individualized thiopurine treatment and reduce the life-threatening cytotoxicity. MET...

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Detalhes bibliográficos
Publicado no:Ann Lab Med
Main Authors: Choi, Rihwa, Chun, Mi Ryung, Park, Jisook, Lee, Ji Won, Ju, Hee Young, Cho, Hee Won, Hyun, Ju Kyung, Koo, Hong Hoe, Yi, Eun Sang, Lee, Soo-Youn
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Laboratory Medicine 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7591283/
https://ncbi.nlm.nih.gov/pubmed/33063676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3343/alm.2021.41.2.145
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