Pursuing the Complexity of Alzheimer’s Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists

Alzheimer’s disease (AD) is a complex disorder with unknown etiology. Currently, only symptomatic therapy of AD is available, comprising cholinesterase inhibitors and N-methyl-d-aspartate (NMDA) receptor antagonists. Drugs targeting only one pathological condition have generated only limited efficac...

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Udgivet i:Biomolecules
Main Authors: Konecny, Jan, Misiachna, Anna, Hrabinova, Martina, Pulkrabkova, Lenka, Benkova, Marketa, Prchal, Lukas, Kucera, Tomas, Kobrlova, Tereza, Finger, Vladimir, Kolcheva, Marharyta, Kortus, Stepan, Jun, Daniel, Valko, Marian, Horak, Martin, Soukup, Ondrej, Korabecny, Jan
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7822176/
https://ncbi.nlm.nih.gov/pubmed/33375115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11010003
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