The pathogenic S688Y mutation in the ligand-binding domain of the GluN1 subunit regulates the properties of NMDA receptors

Although numerous pathogenic mutations have been identified in various subunits of N-methyl-D-aspartate receptors (NMDARs), ionotropic glutamate receptors that are central to glutamatergic neurotransmission, the functional effects of these mutations are often unknown. Here, we combined in silico mod...

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Udgivet i:Sci Rep
Main Authors: Skrenkova, Kristyna, Song, Jae-man, Kortus, Stepan, Kolcheva, Marharyta, Netolicky, Jakub, Hemelikova, Katarina, Kaniakova, Martina, Krausova, Barbora Hrcka, Kucera, Tomas, Korabecny, Jan, Suh, Young Ho, Horak, Martin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596085/
https://ncbi.nlm.nih.gov/pubmed/33122756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-75646-w
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