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Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods

The neuropeptides, orexin A and orexin B (also known as hypocretins), are produced in hypothalamic neurons and belong to ligands for orphan G protein-coupled receptors. Generally, the primary role of orexins is to act as excitatory neurotransmitters and regulate the sleep process. Lack of orexins ma...

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Publicat a:Molecules
Autors principals: Janockova, Jana, Dolezal, Rafael, Nepovimova, Eugenie, Kobrlova, Tereza, Benkova, Marketa, Kuca, Kamil, Konecny, Jan, Mezeiova, Eva, Melikova, Michaela, Hepnarova, Vendula, Ring, Avi, Soukup, Ondrej, Korabecny, Jan
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6278354/
https://ncbi.nlm.nih.gov/pubmed/30423961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23112926
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