Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors

Tacrine was the first drug to be approved for Alzheimer’s disease (AD) treatment, acting as a cholinesterase inhibitor. The neuropathological hallmarks of AD are amyloid-rich senile plaques, neurofibrillary tangles, and neuronal degeneration. The portfolio of currently approved drugs for AD includes...

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Bibliografiske detaljer
Udgivet i:Biomolecules
Main Authors: Svobodova, Barbora, Mezeiova, Eva, Hepnarova, Vendula, Hrabinova, Martina, Muckova, Lubica, Kobrlova, Tereza, Jun, Daniel, Soukup, Ondrej, Jimeno, María Luisa, Marco-Contelles, José, Korabecny, Jan
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6723352/
https://ncbi.nlm.nih.gov/pubmed/31430943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9080379
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