Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer’s Agents: Design, Synthesis and Biological Evaluation

A novel series of 6-chlorotacrine-scutellarin hybrids was designed, synthesized and the biological activity as potential anti-Alzheimer’s agents was assessed. Their inhibitory activity towards human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE), antioxidant activity, ability t...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Spilovska, Katarina, Korabecny, Jan, Sepsova, Vendula, Jun, Daniel, Hrabinova, Martina, Jost, Petr, Muckova, Lubica, Soukup, Ondrej, Janockova, Jana, Kucera, Tomas, Dolezal, Rafael, Mezeiova, Eva, Kaping, Daniel, Kuca, Kamil
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152717/
https://ncbi.nlm.nih.gov/pubmed/28621747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22061006
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