Targeting NPM1 in irradiated cells inhibits NPM1 binding to RAD51, RAD51 foci formation and radiosensitizes NSCLC

The ability of chemo-radiation therapy to control locally advanced stage III non-small cell lung cancer (NSCLC) is poor. While addition of consolidation immunotherapy has improved outcomes in subsets of patients there is still an urgent need for new therapeutic targets. Emerging research indicates t...

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Bibliographic Details
Published in:Cancer Lett
Main Authors: Traver, Geri, Sekhar, Konjeti R., Crooks, Peter A., Keeney, Diane S., Freeman, Michael L.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7822076/
https://ncbi.nlm.nih.gov/pubmed/33358698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2020.12.023
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