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Targeting NPM1 in irradiated cells inhibits NPM1 binding to RAD51, RAD51 foci formation and radiosensitizes NSCLC

The ability of chemo-radiation therapy to control locally advanced stage III non-small cell lung cancer (NSCLC) is poor. While addition of consolidation immunotherapy has improved outcomes in subsets of patients there is still an urgent need for new therapeutic targets. Emerging research indicates t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Lett
Prif Awduron: Traver, Geri, Sekhar, Konjeti R., Crooks, Peter A., Keeney, Diane S., Freeman, Michael L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7822076/
https://ncbi.nlm.nih.gov/pubmed/33358698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2020.12.023
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