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Development and Validation of a Novel Assay to Identify Radiosensitizers that Target Nucleophosmin 1

A series of indole analogs that are synthesized using the scaffold of a potent radiosensitizer, YTR107, were tested for their ability to alter the solubility of phosphorylated nucleophosmin 1 (pNPM1). NPM1 is critical for DNA double strand break (DSB) repair. In response to formation of DNA DSBs, ph...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Penthala, Narsimha R., Crooks, Peter A., Freeman, Michael L., Sekhar, Konjeti R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418231/
https://ncbi.nlm.nih.gov/pubmed/25922180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.04.018
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