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Development and Validation of a Novel Assay to Identify Radiosensitizers that Target Nucleophosmin 1
A series of indole analogs that are synthesized using the scaffold of a potent radiosensitizer, YTR107, were tested for their ability to alter the solubility of phosphorylated nucleophosmin 1 (pNPM1). NPM1 is critical for DNA double strand break (DSB) repair. In response to formation of DNA DSBs, ph...
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| Izdano u: | Bioorg Med Chem |
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| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4418231/ https://ncbi.nlm.nih.gov/pubmed/25922180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.04.018 |
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