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The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double strand breaks, and enhancing radiosensitization

PURPOSE: Radiation therapy continues to be an important therapeutic strategy for providing definitive local/regional control of human cancer. However, oncogenes that harbor driver mutations and/or amplifications can compromise therapeutic efficacy. Thus, there is a need for novel approaches that enh...

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Main Authors: Sekhar, Konjeti R, Reddy, Y. Thirupathi, Reddy, P. Narsimha, Crooks, Peter A, Venkateswaran, Amudhan, McDonald, W. Hayes, Geng, Ling, Sasi, Soumya, Van Der Waal, Robert P., Roti, Joseph L Roti, Salleng, Kenneth J, Rachakonda, Girish, Freeman, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195947/
https://ncbi.nlm.nih.gov/pubmed/21878537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1054
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