Enzymatic Insertion of Lipids Increases Membrane Tension for Inhibiting Cancer Cells

Although lipids contribute to cancer drug resistance, it is challenging to target diverse range of lipids. Here we show enzymatically inserting exceedingly simple synthetic lipids into membranes for increasing membrane tension and selectively inhibiting drug resistant cancer cells. The lipid, formed...

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Vydáno v:Chemistry
Hlavní autoři: Wang, Jiaqing, Tan, Weiyi, Li, Guanying, Wu, Difei, He, Hongjian, Xu, Jiashu, Yi, Meihui, Zhang, Ye, Aghvami, S. Ali, Fraden, Seth, Xu, Bing
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7821352/
https://ncbi.nlm.nih.gov/pubmed/32579262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202002974
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