Intrinsic DNA damage repair deficiency results in progressive microglia loss and replacement

The DNA excision repair protein Ercc1 is important for nucleotide excision, double strand DNA break, and interstrand DNA crosslink repair. In constitutive Ercc1‐knockout mice, microglia display increased phagocytosis, proliferation and an enhanced responsiveness to lipopolysaccharide (LPS)‐induced p...

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Detalhes bibliográficos
Publicado no:Glia
Main Authors: Zhang, Xiaoming, Heng, Yang, Kooistra, Susanne M., van Weering, Hilmar R. J., Brummer, Maaike L., Gerrits, Emma, Wesseling, Evelyn M., Brouwer, Nieske, Nijboer, Tjalling W., Dubbelaar, Marissa L., Boddeke, Erik W. G. M., Eggen, Bart J. L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7821301/
https://ncbi.nlm.nih.gov/pubmed/33068332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23925
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