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Intrinsic DNA damage repair deficiency results in progressive microglia loss and replacement
The DNA excision repair protein Ercc1 is important for nucleotide excision, double strand DNA break, and interstrand DNA crosslink repair. In constitutive Ercc1‐knockout mice, microglia display increased phagocytosis, proliferation and an enhanced responsiveness to lipopolysaccharide (LPS)‐induced p...
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| Veröffentlicht in: | Glia |
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| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley & Sons, Inc.
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7821301/ https://ncbi.nlm.nih.gov/pubmed/33068332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23925 |
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