A Randomized, Single‐Blind, Placebo‐Controlled, 3‐Way Crossover Study to Evaluate the Effect of Therapeutic and Supratherapeutic Doses of Edaravone on QT/QTc Interval in Healthy Subjects

This randomized, single‐blind, 3‐way crossover study assessed the effect of edaravone on QT interval, including an exposure‐response analysis. Twenty‐seven healthy Japanese male volunteers, aged 20 to 49 years, were randomly assigned to receive a single intravenous dose of each treatment in 1 of 3 s...

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Veröffentlicht in:Clin Pharmacol Drug Dev
Hauptverfasser: Shimizu, Hidetoshi, Inoue, Shinsuke, Endo, Mai, Nakamaru, Yoshinobu, Yoshida, Kaori, Natori, Tomoko, Kakubari, Masae, Akimoto, Makoto, Kondo, Kazuoki
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818234/
https://ncbi.nlm.nih.gov/pubmed/32543120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.814
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