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Effect of Therapeutic and Supratherapeutic Doses of Vonoprazan on the QT/QTc Interval in a Phase I Randomized Study in Healthy Subjects

This phase I, randomized, 4‐period, 4‐sequence, double‐blind, active‐ and placebo‐controlled, crossover study assessed the effects of vonoprazan on the QT/QTc interval in healthy subjects. Subjects received single oral doses of vonoprazan 40 mg, vonoprazan 120 mg, moxifloxacin 400 mg (positive contr...

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Détails bibliographiques
Publié dans:Clin Transl Sci
Auteurs principaux: Astruc, B, Jenkins, H, Jenkins, R
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421729/
https://ncbi.nlm.nih.gov/pubmed/28198590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12452
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