Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response

Endonuclease G (ENDOG), a mitochondrial nuclease, is known to participate in many cellular processes, including apoptosis and paternal mitochondrial elimination, while its role in autophagy remains unclear. Here, we report that ENDOG released from mitochondria promotes autophagy during starvation, w...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wang, Wenjun, Li, Jianshuang, Tan, Junyang, Wang, Miaomiao, Yang, Jing, Zhang, Zhi-Min, Li, Chuanzhou, Basnakian, Alexei G., Tang, Hong-Wen, Perrimon, Norbert, Zhou, Qinghua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817833/
https://ncbi.nlm.nih.gov/pubmed/33473107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20780-2
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