An allosteric modulator binds to a conformational hub in the β(2) adrenergic receptor

Most drugs acting on G-protein-coupled receptors target the orthosteric binding pocket where the native hormone or neurotransmitter binds. There is much interest in finding allosteric ligands for these targets because they modulate physiologic signaling and promise to be more selective than orthoste...

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Udgivet i:Nat Chem Biol
Main Authors: Liu, Xiangyu, Kaindl, Jonas, Korczynska, Magdalena, Stößel, Anne, Dengler, Daniela, Stanek, Markus, Hübner, Harald, Clark, Mary J., Mahoney, Jake, Matt, Rachel Ann, Xu, Xinyu, Hirata, Kunio, Shoichet, Brian K., Sunahara, Roger K., Kobilka, Brian K., Gmeiner, Peter
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7816728/
https://ncbi.nlm.nih.gov/pubmed/32483378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0549-2
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