On the correlation of cereblon binding, fluorination and antiangiogenic properties of immunomodulatory drugs

Cereblon (CRBN), the substrate receptor of an E3 ubiquitin ligase complex, is a target of thalidomide and thalidomide-derived immunomodulatory drugs (IMiDs). The binding of these IMiDs to CRBN alters the substrate specificity of the ligase, thereby mediating multiple effects that are exploited in ca...

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Bibliographic Details
Published in:Biochem Biophys Res Commun
Main Authors: Heim, Christopher, Maiwald, Samuel, Steinebach, Christian, Collins, Matthew K., Strope, Jonathan, Chau, Cindy H., Figg, William D., Gütschow, Michael, Hartmann, Marcus D.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815984/
https://ncbi.nlm.nih.gov/pubmed/33310190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2020.11.117
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