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On the correlation of cereblon binding, fluorination and antiangiogenic properties of immunomodulatory drugs
Cereblon (CRBN), the substrate receptor of an E3 ubiquitin ligase complex, is a target of thalidomide and thalidomide-derived immunomodulatory drugs (IMiDs). The binding of these IMiDs to CRBN alters the substrate specificity of the ligase, thereby mediating multiple effects that are exploited in ca...
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| Publicado no: | Biochem Biophys Res Commun |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7815984/ https://ncbi.nlm.nih.gov/pubmed/33310190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2020.11.117 |
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