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In silico analysis of enantioselective binding of immunomodulatory imide drugs to cereblon

BACKGROUND: Thalidomide and its analogs, lenalidomide and pomalidomide (referred to as immunomodulatory imide drugs or IMiDs) have been known to treat multiple myeloma and other hematologic malignancies as well as to cause teratogenicity. Recently the protein cereblon was identified as the primary t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Springerplus
Prif Awduron: Murai, Takahiro, Kawashita, Norihito, Tian, Yu-Shi, Takagi, Tatsuya
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer International Publishing 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949186/
https://ncbi.nlm.nih.gov/pubmed/27478739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40064-016-2761-9
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