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Novel Concepts for Drug Hypersensitivity Based on the Use of Long-Time Scale Molecular Dynamic Simulation

The discovery that several drug hypersensitivity reactions (DHRs) are associated with specific human leukocyte antigen (HLA) alleles has attracted increasing research interest. However, the underlying mechanisms of these HLA-induced DHRs remain unclear, especially for drug-induced immediate activati...

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Detalles Bibliográficos
Publicado en:J Pharm (Cairo)
Main Authors: Murai, Takahiro, Kawashita, Norihito, Tian, Yu-Shi, Takagi, Tatsuya
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5141551/
https://ncbi.nlm.nih.gov/pubmed/27999707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/9520361
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