Novel Concepts for Drug Hypersensitivity Based on the Use of Long-Time Scale Molecular Dynamic Simulation

The discovery that several drug hypersensitivity reactions (DHRs) are associated with specific human leukocyte antigen (HLA) alleles has attracted increasing research interest. However, the underlying mechanisms of these HLA-induced DHRs remain unclear, especially for drug-induced immediate activati...

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Vydáno v:J Pharm (Cairo)
Hlavní autoři: Murai, Takahiro, Kawashita, Norihito, Tian, Yu-Shi, Takagi, Tatsuya
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5141551/
https://ncbi.nlm.nih.gov/pubmed/27999707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/9520361
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