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Constitutive Activity of Serotonin Receptor 6 Regulates Human Cerebral Organoids Formation and Depression-like Behaviors

Serotonin receptor 6 (5-HT(6)R), a typical G protein-coupled receptor (GPCR) mainly expressed in the neurogenic area with constitutive activity, is of particular interest as a promising target for emotional impairment. Here, we found that 5-HT(6)R was highly expressed in human NSCs and activation of...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Stem Cell Reports
Prif Awduron: Wang, Qinying, Dong, Xiaoxu, Hu, Tingting, Qu, Chao, Lu, Jing, Zhou, Yue, Li, Jinsong, Pei, Gang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815944/
https://ncbi.nlm.nih.gov/pubmed/33357407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.11.015
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