HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

Inflammasomes are supramolecular complexes that play key roles in immune surveillance. This is accomplished by activating inflammatory caspases, which lead to the proteolytic maturation of IL-1β and pyroptosis. Here, we show that NLRP3- and pyrin-mediated inflammasome assembly, caspase activation, a...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Science
Egile Nagusiak: Magupalli, Venkat Giri, Negro, Roberto, Tian, Yuzi, Hauenstein, Arthur V., Caprio, Giuseppe Di, Skillern, Wesley, Deng, Qiufang, Orning, Pontus, Alam, Hasan B., Maliga, Zoltan, Sharif, Humayun, Hu, Jun Jacob, Evavold, Charles L., Kagan, Jonathan C., Schmidt, Florian I., Fitzgerald, Katherine A., Kirchhausen, Tomas, Li, Yongqing, Wu, Hao
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814939/
https://ncbi.nlm.nih.gov/pubmed/32943500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aas8995
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