HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

Inflammasomes are supramolecular complexes that play key roles in immune surveillance. This is accomplished by activating inflammatory caspases, which lead to the proteolytic maturation of IL-1β and pyroptosis. Here, we show that NLRP3- and pyrin-mediated inflammasome assembly, caspase activation, a...

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Gepubliceerd in:Science
Hoofdauteurs: Magupalli, Venkat Giri, Negro, Roberto, Tian, Yuzi, Hauenstein, Arthur V., Caprio, Giuseppe Di, Skillern, Wesley, Deng, Qiufang, Orning, Pontus, Alam, Hasan B., Maliga, Zoltan, Sharif, Humayun, Hu, Jun Jacob, Evavold, Charles L., Kagan, Jonathan C., Schmidt, Florian I., Fitzgerald, Katherine A., Kirchhausen, Tomas, Li, Yongqing, Wu, Hao
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814939/
https://ncbi.nlm.nih.gov/pubmed/32943500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aas8995
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