Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression

Animal models recapitulating distinctive features of severe COVID-19 are critical to enhance our understanding of SARS-CoV-2 pathogenesis. Transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) under the cytokeratin 18 promoter (K18-hACE2) represent a lethal model of SARS-CoV-2 inf...

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I publikationen:bioRxiv
Huvudupphovsmän: Carossino, Mariano, Montanaro, Paige, O'Connell, Aoife, Kenney, Devin, Gertje, Hans, Grosz, Kyle, Ericsson, Maria, Huber, Bertrand R, Subramaniam, Saravanan, Kirkland, Thomas A, Walker, Joel R, Francis, Kevin P, Klose, Alexander D, Paragas, Neal, Kurnick, Susanna, Bosmann, Markus, Saeed, Mohsan, Balasuriya, Udeni, Douam, Florian, Crossland, Nicholas
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory 2021
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814818/
https://ncbi.nlm.nih.gov/pubmed/33469581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.01.13.425144
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