Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression

Animal models recapitulating distinctive features of severe COVID-19 are critical to enhance our understanding of SARS-CoV-2 pathogenesis. Transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) under the cytokeratin 18 promoter (K18-hACE2) represent a lethal model of SARS-CoV-2 inf...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Carossino, Mariano, Montanaro, Paige, O'Connell, Aoife, Kenney, Devin, Gertje, Hans, Grosz, Kyle, Ericsson, Maria, Huber, Bertrand R, Subramaniam, Saravanan, Kirkland, Thomas A, Walker, Joel R, Francis, Kevin P, Klose, Alexander D, Paragas, Neal, Kurnick, Susanna, Bosmann, Markus, Saeed, Mohsan, Balasuriya, Udeni, Douam, Florian, Crossland, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814818/
https://ncbi.nlm.nih.gov/pubmed/33469581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.01.13.425144
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