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Studying Histone Deacetylase Inhibition and Apoptosis Induction of Psammaplin A Monomers with Modified Thiol Group

[Image: see text] Psammaplin A (PsA) is a bromotyrosine disulfide dimer with histone deacetylase (HDAC) inhibition and acts through reduced monomer PsA-SH. We studied the connection of HDAC inhibition, cell growth inhibition, and apoptosis induction of PsA-SH by modifying the −SH group with deletion...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Bao, Yu, Xu, Qihao, Wang, Lin, Wei, Yunfei, Hu, Baichun, Wang, Jian, Liu, Dan, Zhao, Linxiang, Jing, Yongkui
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2021
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7812609/
https://ncbi.nlm.nih.gov/pubmed/33488962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00369
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