The Effect of Verapamil, a P-gp Inhibitor, on the Pharmacokinetics, Safety, and Tolerability of Omadacycline in Healthy Adults: A Phase I, Open-Label, Single-Sequence Study

BACKGROUND: Omadacycline is a semisynthetic aminomethylcycline antibacterial derived from the tetracycline class. It is approved in the USA to treat adults with acute bacterial skin and skin-structure infections and community-acquired bacterial pneumonia. OBJECTIVES: This phase I, open-label study e...

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Vydáno v:Eur J Drug Metab Pharmacokinet
Hlavní autoři: Hunt, Thomas L., Tzanis, Evan, Bai, Stephen, Manley, Amy, Chitra, Surya, McGovern, Paul C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2020
Témata:
Original Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7811981/
https://ncbi.nlm.nih.gov/pubmed/33180250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13318-020-00651-3
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