Safety and Pharmacokinetics of the Aminomethylcycline Antibiotic Omadacycline Administered to Healthy Subjects in Oral Multiple-Dose Regimens

Omadacycline, a first-in-class aminomethylcycline antibiotic, is related to tetracyclines but is structurally modified to circumvent mechanisms of resistance to tetracyclines. Omadacycline demonstrates potent activity against a broad range of pathogens, including drug-resistant strains, and is in la...

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Enregistré dans:
Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Bundrant, Lu Ann, Tzanis, Evan, Garrity-Ryan, Lynne, Bai, Stephen, Chitra, Surya, Manley, Amy, Villano, Stephen
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2018
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786815/
https://ncbi.nlm.nih.gov/pubmed/29180524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01487-17
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