Comparison of Omadacycline and Tigecycline Pharmacokinetics in the Plasma, Epithelial Lining Fluid, and Alveolar Cells of Healthy Adult Subjects

The steady-state concentrations of omadacycline and tigecycline in the plasma, epithelial lining fluid (ELF), and alveolar cells (AC) of 58 healthy adult subjects were obtained. Subjects were administered either omadacycline at 100 mg intravenously (i.v.) every 12 h for two doses followed by 100 mg...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Gotfried, Mark H., Horn, Karolyn, Garrity-Ryan, Lynne, Villano, Stephen, Tzanis, Evan, Chitra, Surya, Manley, Amy, Tanaka, S. Ken, Rodvold, Keith A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571291/
https://ncbi.nlm.nih.gov/pubmed/28696233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01135-17
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