Comparison of Omadacycline and Tigecycline Pharmacokinetics in the Plasma, Epithelial Lining Fluid, and Alveolar Cells of Healthy Adult Subjects

The steady-state concentrations of omadacycline and tigecycline in the plasma, epithelial lining fluid (ELF), and alveolar cells (AC) of 58 healthy adult subjects were obtained. Subjects were administered either omadacycline at 100 mg intravenously (i.v.) every 12 h for two doses followed by 100 mg...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Gotfried, Mark H., Horn, Karolyn, Garrity-Ryan, Lynne, Villano, Stephen, Tzanis, Evan, Chitra, Surya, Manley, Amy, Tanaka, S. Ken, Rodvold, Keith A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571291/
https://ncbi.nlm.nih.gov/pubmed/28696233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01135-17
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