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Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis
Mycobacterium tuberculosis secretes the tuberculosis necrotizing toxin (TNT) to kill host cells. Here, we show that the WXG100 proteins EsxE and EsxF are essential for TNT secretion. EsxE and EsxF form a water-soluble heterodimer (EsxEF) that assembles into oligomers and long filaments, binds to mem...
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| Pubblicato in: | Nat Commun |
|---|---|
| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7810871/ https://ncbi.nlm.nih.gov/pubmed/33452244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20533-1 |
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