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Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis
Mycobacterium tuberculosis secretes the tuberculosis necrotizing toxin (TNT) to kill host cells. Here, we show that the WXG100 proteins EsxE and EsxF are essential for TNT secretion. EsxE and EsxF form a water-soluble heterodimer (EsxEF) that assembles into oligomers and long filaments, binds to mem...
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| Published in: | Nat Commun |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group UK
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7810871/ https://ncbi.nlm.nih.gov/pubmed/33452244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20533-1 |
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