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Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis
Mycobacterium tuberculosis secretes the tuberculosis necrotizing toxin (TNT) to kill host cells. Here, we show that the WXG100 proteins EsxE and EsxF are essential for TNT secretion. EsxE and EsxF form a water-soluble heterodimer (EsxEF) that assembles into oligomers and long filaments, binds to mem...
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| Gepubliceerd in: | Nat Commun |
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| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group UK
2021
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7810871/ https://ncbi.nlm.nih.gov/pubmed/33452244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20533-1 |
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