Cadmium Exposure Activates Akt/ERK Signaling and Pro-Inflammatory COX-2 Expression in Human Gallbladder Epithelial Cells via a ROS Dependent Mechanism.

Gallbladder cancer (GBC) is the commonest biliary tract cancer with an ill-defined etiology. We examined the role of Cd(+2) exposures in a primary human gallbladder (GB) cell line model in this study. Cd(+2) exposures induced decreased cell viability, reactive oxygen species (ROS) generation, altere...

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Vydáno v:Toxicol In Vitro
Hlavní autoři: Sharma, Priyanka, Caldwell, Trevar S., Rivera, Megan N., Gullapalli, Rama R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809918/
https://ncbi.nlm.nih.gov/pubmed/32512147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tiv.2020.104912
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