Cadmium Increases HIF-1 and VEGF Expression through ROS, ERK, and AKT Signaling Pathways and Induces Malignant Transformation of Human Bronchial Epithelial Cells

Cadmium is categorized as a human carcinogen especially involved in lung cancers. Angiogenesis is considered a fundamental requirement for tumorigenesis, but the mechanisms underlying the tumor angiogenesis induced by cadmium are poorly understood. Using in vitro and in vivo models, we investigated...

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Detalhes bibliográficos
Main Authors: Jing, Yi, Liu, Ling-Zhi, Jiang, Yue, Zhu, Yingxue, Guo, Nancy Lan, Barnett, John, Rojanasakul, Yon, Agani, Faton, Jiang, Bing-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Carcinogenicity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243743/
https://ncbi.nlm.nih.gov/pubmed/21984483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfr256
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