Inactive variants of death receptor p75(NTR) reduce Alzheimer’s neuropathology by interfering with APP internalization

A prevalent model of Alzheimer’s disease (AD) pathogenesis postulates the generation of neurotoxic fragments derived from the amyloid precursor protein (APP) after its internalization to endocytic compartments. The molecular pathways that regulate APP internalization and intracellular trafficking in...

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Veröffentlicht in:EMBO J
Hauptverfasser: Yi, Chenju, Goh, Ket Yin, Wong, Lik‐Wei, Ramanujan, Ajeena, Tanaka, Kazuhiro, Sajikumar, Sreedharan, Ibáñez, Carlos F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809794/
https://ncbi.nlm.nih.gov/pubmed/33258176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104450
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