Inactive variants of death receptor p75(NTR) reduce Alzheimer’s neuropathology by interfering with APP internalization

A prevalent model of Alzheimer’s disease (AD) pathogenesis postulates the generation of neurotoxic fragments derived from the amyloid precursor protein (APP) after its internalization to endocytic compartments. The molecular pathways that regulate APP internalization and intracellular trafficking in...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:EMBO J
Main Authors: Yi, Chenju, Goh, Ket Yin, Wong, Lik‐Wei, Ramanujan, Ajeena, Tanaka, Kazuhiro, Sajikumar, Sreedharan, Ibáñez, Carlos F.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809794/
https://ncbi.nlm.nih.gov/pubmed/33258176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104450
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