Inactive variants of death receptor p75(NTR) reduce Alzheimer’s neuropathology by interfering with APP internalization

A prevalent model of Alzheimer’s disease (AD) pathogenesis postulates the generation of neurotoxic fragments derived from the amyloid precursor protein (APP) after its internalization to endocytic compartments. The molecular pathways that regulate APP internalization and intracellular trafficking in...

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Vydáno v:EMBO J
Hlavní autoři: Yi, Chenju, Goh, Ket Yin, Wong, Lik‐Wei, Ramanujan, Ajeena, Tanaka, Kazuhiro, Sajikumar, Sreedharan, Ibáñez, Carlos F.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809794/
https://ncbi.nlm.nih.gov/pubmed/33258176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104450
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