Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures

Both high-fidelity and mismatch-tolerant recombination, catalyzed by RAD51 and DMC1 recombinases, respectively, are indispensable for genomic integrity. Here, we use cryo-EM, MD simulation and functional analysis to elucidate the structural basis for the mismatch tolerance of DMC1. Structural analys...

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Vydáno v:Nat Commun
Hlavní autoři: Luo, Shih-Chi, Yeh, Hsin-Yi, Lan, Wei-Hsuan, Wu, Yi-Min, Yang, Cheng-Han, Chang, Hao-Yen, Su, Guan-Chin, Lee, Chia-Yi, Wu, Wen-Jin, Li, Hung-Wen, Ho, Meng-Chiao, Chi, Peter, Tsai, Ming-Daw
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809202/
https://ncbi.nlm.nih.gov/pubmed/33446654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20258-1
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