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Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures
Both high-fidelity and mismatch-tolerant recombination, catalyzed by RAD51 and DMC1 recombinases, respectively, are indispensable for genomic integrity. Here, we use cryo-EM, MD simulation and functional analysis to elucidate the structural basis for the mismatch tolerance of DMC1. Structural analys...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7809202/ https://ncbi.nlm.nih.gov/pubmed/33446654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20258-1 |
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