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Synthesis of amide derivatives for electron deficient amines and functionalized carboxylic acids using EDC and DMAP and a catalytic amount of HOBt as the coupling reagents

A convenient protocol for amide bond formation for electron deficient amines and carboxylic acids is described. Amide coupling of aniline derivatives has been investigated with a number of reagents under a variety of reaction conditions. The use of 1 equivalent of EDC and 1 equivalent of DMAP, catal...

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Pubblicato in:Tetrahedron Lett
Autori principali: Ghosh, Arun K., Shahabi, Dana
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808253/
https://ncbi.nlm.nih.gov/pubmed/33456089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2020.152719
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